The prevention of AGE-included apoptosis and endoplasmic reticulum stress by iRAGE

JS MaltaisDr Jean-Sébastien Maltais, from Sherbrooke University, Canada was invited to take part to the 3rd World Congress on Glycation, which will be held in Budapest next May 26-27, 2016 to talk about the iRAGE as a novel carboxymethylated peptide to prevent AGE-included apoptosis and endoplasmic reticulum stress in vascular smooth muscle cells.

According Dr Maltais and his team, the overexpression of RAGE in smooth muscle cells of vulnerable atheromatous plaques suggests the receptor could contribute to cardiovascular complications of diabetes. Dr Maltais's team suggests a model by which iRAGE inhibits RAGE signaling by hindering the binding of multimeric ligands and by stabilizing the receptors in a monomer state.

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