AGEs in obesity and its complications

Casper Schalkwijk Carim
The scientific committee of Maillard Reaction & Glycation World Congress 2016 is honoured to welcoming prof. Casper G. Schalkwijk from Department of Internal Medicine, Laboratory of Metabolism and Vascular Medicine, Maastricht University Medical Center in The Netherlands to give a presentation about AGEs in obesity and its complications.

According to prof. Schalkwijk, the
development of obesity is one of the largest health problems worldwide.
‘’
We have recently demonstrated that advanced glycation endproducts (AGEs) accumulate in adipose tissue, and that they contribute to complications such as insulin resistance and type 2 diabetes via an inflammatory reaction in adipose tissue.
We recently investigated the effect of a delayed PM intervention on metabolic and vascular function in high-fat diet (HFD)-induced obese mice. We found that PM-treated, HFD-induced obese mice had reduced body weight gain, hyperglycemia and hypercholesterolemia, as compared to those who were not treated with PM.’’


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