The role of skin collagen pentosidine and fluorescence as predictor of creatininemia increase and retinopathy progression

michel Sternberg
Prof. Michel Sternberg is working in Université René Descartes in Paris, France. During Glycation & Maillard Reaction  Congress which will be held  in Budapest on May 26-27, 2016 he will give a presentation about skin collagen pentosidine and fluorescence in diabetes are predictors of creatininemia increase and retinopathy progression already 6 years after punch-biopsy.

The team of prof. Sternberg measured pentosidine and fluorescence at 370/440nm in collagen extracted from skin punch-biopsies in 30 patients with diabetes (14 type 1 diabetes and 16 type 2 diabetes) without renal insufficiency, and in age- and gender-matched normoglycemic controls, followed at Hôtel-Dieu in Paris. At the time of biopsy, marked increases in pentosidine and fluorescence  levels, expressed per collagen hydroxyproline, were found in the patients with diabetes versus normoglcemic controls. Pentosidine and fluorescence were correlated with diabetes duration. Fluorescence was significantly dependent on retinopathy presence and score in type-1 and type-2 diabetes. Fluorescence was correlated with microalbuminuria, only in type-1 diabetes. Already six years after biopsy, retinopathy score progression and creatininemia increase were significantly correlated with initial pentosidine and fluorescence levels.

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