Poly-ADP-ribosylation: oxidative stress signaling and beyond: The state of the science and perspectives

viragPoly-ADP-ribosylation is an NAD-dependent protein modification reaction. In various oxidative stress-related paradigms DNA breaks activate poly(ADP-ribose) polymerase (PARP) enzymes which in turn modify target proteins with NAD-derived (ADP-ribose)n polymers. This reversible protein modification regulates transcription, kinase cascades, metabolism, differentiation, autophagy, cell death only to name a few cell functions and fates. Moreover, it leads to diverse biological outcomes with wide ranging implications for diseases as diverse as diabetes, inflammation, ischemia-reperfusion injury and cancer.

During Glycation World Congress, Pr László Virág from the University of Debrecen, Hungary, will discuss the mechanisms of Poly-ADP-ribosylation: oxidative stress signaling and beyond.

To know more about the congress: www.glycation-site.com